Workaholism tied to psychiatric disorders
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The public goods hypothesis for the evolution of life on Earth.
It is becoming increasingly difficult to reconcile the observed extent of horizontal gene transfers with the central metaphor of a great tree uniting all evolving entities on the planet.
The Landscape for Epigenetic/ Epigenomic Biomedical Resources
[lead]Abstract:[/lead] Recent advances in molecular biology and computational power have seen the biomedical sector enter a new era, with corresponding development of Bioinformatics as a major discipline. Generation of enormous amounts of data has driven the need for more advanced storage solutions and shared access through a range of public repositories. The number of such biomedical…
Selection and the cell cycle: Positive Darwinian Selection in a well-known DNA damage response pathway
Cancer is a common occurrence in multi-cellular organisms and is not strictly limited to the elderly in a population. It is therefore possible that individuals with genotypes that protect against early onset cancers have a selective advantage. In this study the patterns of mutation in the proteins of a well-studied DNA damage response pathway have been examined…
Poverty marks a gene, predicting depression
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Of mice and men
Super treat in the lab this week. The journal Science decided to feature one of our publications in its “Editor’s Choice” section. The author of the little piece is Laura Zahn and she chose to feature the work, which was published in Molecular Biology and Evolution. It is always a real thrill to have work…
Heterogeneous Models place the Root of the Placental Mammal Phylogeny.
[dropcap style=”normal or inverse or boxed”]H[/dropcap]ow are mammals related to one another ? This question has puzzled biologists for decades. In our most recent publication we describe how, using sequence data and sophisticated phylogenetic models, we have resolved this issue. Our analysis shows that the root of the placental mammal phylogeny is the common ancestor…
Functional consequence of positive selection revealed through rational mutagenesis of human myeloperoxidase
Myeloperoxidase (MPO) is a member of the mammalian heme peroxidase (MHP) multigene family. Whereas all MHPs oxidize specific halides to generate the corresponding hypohalous acid, MPO is unique in its capacity to oxidize chloride at physiologic pH to produce hypochlorous acid (HOCl), a potent microbicide that contributes to neutrophil-mediated host defense against infection.
Crisis Hotline Approach Is Changing the Way We Deal With Stress
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