Cover of Structure (Cell Press)

In a recent collaboration with Joe Cockburn et al published in Structure – we reveal the structure of the cargo binding TPR domain of kinesin light chain bound to the cargo molecule JIP3. Along with solving the crystal structure – the biophysical and evolutionary analysis we carried out have revealed the kinesin-1 cargo binding site is conserved right across the metazoa from sponges to humans. We propose a mechanism by which multiple, unrelated cellular cargo molecules can “hotwire” the kinesin-1 molecule into motility.


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