Cover of Structure (Cell Press)

In a recent collaboration with Joe Cockburn et al published in Structure – we reveal the structure of the cargo binding TPR domain of kinesin light chain bound to the cargo molecule JIP3. Along with solving the crystal structure – the biophysical and evolutionary analysis we carried out have revealed the kinesin-1 cargo binding site is conserved right across the metazoa from sponges to humans. We propose a mechanism by which multiple, unrelated cellular cargo molecules can “hotwire” the kinesin-1 molecule into motility.

Link to the paper here:

Citation: Cockburn JJB, Hesketh, SJ, Mulhair PJ, O’Connell MJ, and Way M. “Insights into Kinesin-1 activation from the crystal structure of KLC2 bound to JIP3.” Structure (Cell Press) 2018 Nov 6;26(11):1486-1498.e6. doi: 10.1016/j.str.2018.07.011.



This is the administrative account for the Computational & Molecular Evolutionary Biology Group at the University of Leeds. Please browse through our site and contact us if you have any questions.

'Cover of Structure (Cell Press)' have no comments

Be the first to comment this post!

Would you like to share your thoughts?

Your email address will not be published.


We are always looking for collaborators and new people to come and work with us. Please get in contact if you are interested in what we do: